Mock53 - Digestion and Absorption Medical Biochemistry...

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Unformatted text preview: Digestion and Absorption Medical Biochemistry Lecture #53 Lecture Schedule • Digestion & Absorption – March 27, 10 a.m., Friday • Lipid-soluble Vitamins – March 30, 10 a.m., Friday • Nutrition & Metabolic Integration – March 30, 1 p.m., Friday • Water-soluble Vitamins I – April 2, 9 a.m., Monday • Water-soluble Vitamins II – April 4, 9 a.m., Wednesday • Dennis McGarry – April 5, 8 a.m., Thursday Organ Industrial Function Mouth Intake and grinding unit Esophagus Conveyor belt Stomach Pancreas Acidification/sterilization Acidification/sterilization /emulsification chamber and osmostat Buffer and catalyst tank Buffer Liver Detergent tank Duodenum Mixer for buffer, catalyst, Mixer and detergent and Organ Industrial Function Jejunum Emulsification/reaction Emulsification/reaction chamber chamber Early separation Ileum Late separation Late Reagent reclamation Reagent Colon Salt and water reclamation Fermentation chamber for Fermentation energy reclamation energy Rectum/Anus Sensory (not storage) chamber Sensory Emission control device Emission Three Macronutrients • • • • Fat Protein Carbohydrate Micronutrients = everything else – Vitamins – Macrominerals Ca, P, Na, Cl, K, & Mg – Microminerals Carbohydrate Digestion & Absorption Intestinal Intraluminal Brush Border maltase Maltose Starch Maltoriose maltase Glucose α -amylase α -dextrins α -dextrinase Sucrose sucrase Glucose Fructose Lactose Galactose lactase Glucose Cell Transport active transport active transport facilitated diffusion active transport Activities of Lactase and Other Activities Dissacharidases in Mucosal Biopsies Dissacharidases 350 Units/g protein 300 250 Normal Lactase Deficient 200 150 100 50 0 se se se ra l ta ta a al uc S M om s I se ta ac L CHO Digestion & Absorption CHO Pepsin Initiates Protein Digestion • • • • Pepsinogen is the zymogen Acid and autocatlysis Endopeptidase Not quantitatively important Protein Digestion & Absorption Intestinal Intraluminal Brush Border Carboxypeptidase Protein Amino acids Trypsin Trypsin Chymotrypsin Elastase Dipeptidases Peptides Amino acids Amino peptidase Amino acids Cell Transport active transport active transport active transport Role of Zymogens in Protein Digestion • Zymogens • Pancreatitis • Enteropeptidase comes from the intestinal mucosa • Enzyme cascade ...
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This note was uploaded on 12/16/2011 for the course BIOLOGY 101 taught by Professor Mr.wallace during the Fall '11 term at Montgomery College.

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