Mock56 - Lipid-Soluble Vitamins Medical Biochemistry...

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Unformatted text preview: Lipid-Soluble Vitamins Medical Biochemistry Lecture #56 Organization of Vitamin Information Structure of the vitamin Function of the vitamin Signs & symptoms of deficiency Sources & circumstances leading to deficiency Signs and symptoms of toxicity History of Vitamin Research: Vitamin A vs. Vitamin B Lipid extraction = A Water extraction = B Vitamins A, D, and E Vitamin K B was complex. Fat-soluble Vitamin Deficiencies in Children with Cholestasis Vitamin K (prothrombin time < 80%) 26% Vitamin A (< 30% g/dL) 35% Vitamin E (mgE/g lipid < 0.6) 66% Vitamin D (25 - OH < 14 g/dL 66% N = 23 Isoprene Retinol (Vitamin A) CH 2 OH -carotene H C O O C H -carotene Dioxygenase O 2 Bile salts Retinaldehyde Retinaldehyde -carotene is Converted to Vitamin A Retinal is Reduced to Retinol H C O Retinaldehyde Retinaldehyde Reductase NADPH (NADH) + H + NADP + (NAD + ) CH 2 OH Retinol Retinal can be Oxidized to Retinoic Acid NAD, FAD OH C O Retinoic acid (all- trans ) H C O Retinaldehyde Role of 11- cis-retinal in the Visual Cycle Binding Proteins & Receptors for the Various Forms of Vitamin A Retinol-binding protein (RBP): plasma transport Cellular retinoid-binding...
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Mock56 - Lipid-Soluble Vitamins Medical Biochemistry...

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