mock58 - Water Soluble Vitamins Form Functional Units of...

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Unformatted text preview: Water Soluble Vitamins Form Functional Units of Coenzymes Precursor Precursor Vitamin Vitamin coenzyme coenzyme + enzyme + enzyme Product Product Exception: Ascorbic acid (Vitamin C) Exception: Ascorbic acid (Vitamin C) Deficiency of Water Soluble Vitamins Pathophysiology is result of reduced enzyme activities. Multiple deficiencies are common. Diagnostic Challenge? To recognize multiple findings. Drugs may act as Vitamin Analogs (Media Serv) Toxicity of Water Soluble Vitamins Toxicity recapitulates deficiency if co-enzyme vitamin Enzyme inactivation Thiamin, Riboflavin, Niacin, Niacin, Pyridoxine, Folic acid Not Biotin or Vitamin C Dry Beriberi Causes of Water Soluble Vitamin Deficiency Decreased intake Decreased absorption Enhanced loss during enterohepatic circulation Requirement Pregnancy Decreased Precursor Inborn error of metabolism TPP-ATP Phosphoryltransferase Thiamine Thiamine TPP TPP ATP ATP Thiamine-ATP Thiamine-ATP Phosphoryl Transferase Phosphoryl Transferase TPP TPP Conversion of Pyruvate to acetyl...
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mock58 - Water Soluble Vitamins Form Functional Units of...

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