mock58 - Water Soluble Vitamins Form Functional Units of...

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Unformatted text preview: Water Soluble Vitamins Form Functional Units of Coenzymes Precursor Precursor Vitamin Vitamin coenzyme coenzyme + enzyme + enzyme Product Product Exception: Ascorbic acid (Vitamin C) Exception: Ascorbic acid (Vitamin C) Deficiency of Water Soluble Vitamins • Pathophysiology is result of reduced enzyme activities. • Multiple deficiencies are common. • Diagnostic Challenge? To recognize multiple findings. Drugs may act as Vitamin Analogs (Media Serv) Toxicity of Water Soluble Vitamins • Toxicity recapitulates deficiency if co-enzyme ≠ vitamin • Enzyme inactivation • Thiamin, Riboflavin, Niacin, Niacin, Pyridoxine, Folic acid • Not Biotin or Vitamin C Dry Beriberi Causes of Water Soluble Vitamin Deficiency • Decreased intake • Decreased absorption – Enhanced loss during enterohepatic circulation • Requirement – Pregnancy • Decreased Precursor – Inborn error of metabolism TPP-ATP Phosphoryltransferase Thiamine Thiamine TPP TPP ATP ATP Thiamine-ATP Thiamine-ATP Phosphoryl Transferase Phosphoryl Transferase TPP TPP Conversion of Pyruvate to acetyl...
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This note was uploaded on 12/16/2011 for the course BIOLOGY 101 taught by Professor Mr.wallace during the Fall '11 term at Montgomery College.

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mock58 - Water Soluble Vitamins Form Functional Units of...

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