raney63 - Proline biosynthesis Cysteine is not...

Info iconThis preview shows pages 1–17. Sign up to view the full content.

View Full Document Right Arrow Icon
Amino Acid Metabolism
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Essential Amino Acids Essential amino acids must be consumed in the diet. Mammalian cells lack enzymes to synthesize their carbon skeletons ( α -keto acids). These include: Lysine Threonine Tryptophan Phenylalanine (Tyr can be made from Phe.) Methionine (Cys can be made from Met.) Histidine (Essential for infants.)
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Reductive amination catalyzed by glutamate dehydrogenase
Background image of page 4
Glutamine synthesis is coupled to hydrolysis of ATP
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Pyruvate is an amphibolic intermediate in synthesis of alanine
Background image of page 6
Asparagine synthesis is energetically favorable due to coupling to ATP hydrolysis
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Serine biosynthesis
Background image of page 8
Multistep pathway for glycine biosynthesis
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Glycine is also synthesized from serine
Background image of page 10
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 12
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 14
Background image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 16
Background image of page 17
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Proline biosynthesis Cysteine is not nutritionally essential, however it is derived from methionine +NH 3 CH C H 2 C O-O H 2 C S CH 3 Tyrosine is formed from phenylalanine Hydroxyproline is formed after protein synthesis Selenocysteine is synthesized from serine and selenophosphate Amino acids that are synthesized de novo in humans. All are related by a small number of steps to glycolysis or TCA cycle intermediates. Salvage pathways for formation of certain nonessential amino acids from other amino acids Amino Acid formed Precursor Amino Acid Arginine Proline Cysteine Methionine Tyrosine Phenylalanine...
View Full Document

Page1 / 17

raney63 - Proline biosynthesis Cysteine is not...

This preview shows document pages 1 - 17. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online