raney65 - Catabolism of proteins and amino acids Reactions...

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Catabolism of proteins and amino acids
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Reactions in the attachment of ubiquitin to proteins
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Relationships among major pathways in nitrogen catabolism
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The alpha amino acid nitrogen is channeled into glutamate.
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Transaminase Roles Transaminases equilibrate amino groups among available α - keto acids. This permits synthesis of non-essential amino acids, using amino groups from other amino acids & carbon skeletons synthesized in a cell. Thus a balance of different amino acids is maintained, as proteins of varied amino acid contents are synthesized. Although the amino N of one amino acid can be used to synthesize another amino acid, N must be obtained in the diet as amino acids (proteins).
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Transaminases function in amino acid catabolism and biosynthesis
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Example of a Transaminase reaction: Aspartate donates its amino group, becoming the α -keto acid oxaloacetate. α -Ketoglutarate accepts the amino group, becoming the amino acid glutamate. aspartate α -ketoglutarate oxaloacetate glutamate Aminotransferase (Transaminase) COO - CH 2 CH 2 C COO - O COO - CH 2 HC COO - NH 3 + COO - CH 2 CH 2 HC COO - NH 3 + COO - CH 2 C COO - O + +
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The prosthetic group of Transaminase is pyridoxal phosphate ( PLP ), a derivative of vitamin B 6 . pyridoxal phosphate (PLP) N H C O P O - O O OH CH 3 C H O - + H 2
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In the resting state, the aldehyde group of pyridoxal phosphate is in a Schiff base linkage to the ε -amino group of an enzyme lysine residue.
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This note was uploaded on 12/16/2011 for the course BIOLOGY 101 taught by Professor Mr.wallace during the Fall '11 term at Montgomery College.

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raney65 - Catabolism of proteins and amino acids Reactions...

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