wheeler59 - Risk Factors for Premature Atherosclerotic...

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Unformatted text preview: Risk Factors for Premature Atherosclerotic Heart Disease Dyslipidemia (high LDL, low HDL) Diabetes Hypertension Obesity Sedentary lifestyle Obesity Smoking Male sex Hyperhomocysteinemia Homocysteine Non-protein-forming, sulfur-containing amino acid Formed exclusively by demethylation of methionine Eliminated through one of two vitamin-dependent pathways, in addition to an alternate vitamin- independent pathway in liver Hyperhomocysteinemia Independent risk factor for atherosclerotic and thromboembolic disease A 5 M increase in serum level confers a 80% increased risk to women and a 60% increased risk to men for atherosclerotic vascular disease In patients with coronary artery disease, serum homocysteine levels increase with the number of stenosed coronary vessels Hyperhomocysteinemia may reflect: Genetic defects Folate (most common), pyridoxine (vitamin B 6 ), or cobalamin (vitamin B 12 ) deficiencies Renal failure Serum levels of homocysteine may be lowered by supplementation with folate, vitamin B 6 , and vitamin B 12 QuickTime and a...
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This note was uploaded on 12/16/2011 for the course BIOLOGY 101 taught by Professor Mr.wallace during the Fall '11 term at Montgomery College.

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wheeler59 - Risk Factors for Premature Atherosclerotic...

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