Lecture 8 - Regulation of Gene Expression Eukryotic 04-04-11

Lecture 8 - Regulation of Gene Expression Eukryotic...

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Unformatted text preview: !"#$%$&$%' )*+ ,-.)#/$012 3'*' ,45#'&&1$* 6'7-8)01$* 9'20-#'# : ;<=>?=>> !")50'# >>@ >A@ )*+ >B Chromosomes (Ch 11) ¡ In prokaryotes, the circular DNA molecule containing the entire set of genetic information. ¡ In the eukaryotic nucleus, one of the threadlike structures consisting of a single DNA molecule packaged in a protein complex. ¡ Chromosome: structure of organized DNA in eukaryotic cell. Human Cell Nucleus: 5 ± ȝ m Genome: 6.4 x 10 9 bp 1 bp = 0.34 nm DNA length = 6.4 x 10 9 x 0.34 = 2.2 meters of DNA in human nucleus Chromosomes Eukaryotic DNA organization ± DNA ± DNA + histones = Nucleosomes ± 1/3 reduction in DNA length ± Nucleosomes fold up and compress = Chromatin fiber ± Further condensed ± Chromatin Fiber ± coiled into a chromatid ± Chromatids constitute a chromosome ¡ Proteins package chromatin ¾ 2 each of H2A, H2B, H3, and H4, so 8 histone proteins in the core ± histone octamer ¾ One H1 histone between nucleosomes Chromosomes Chromosomes ¡ Between cell divisions much of the chromatin is relaxed (un-coiled). ¡ Euchromatin and heterochromatin. ± Euchromatin ± refers to the decondensed areas....
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This note was uploaded on 12/16/2011 for the course AGR 3303 taught by Professor Gallio during the Summer '08 term at University of Florida.

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Lecture 8 - Regulation of Gene Expression Eukryotic...

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