Lecture 15 - Chromosomal Variations updated slides 06-01-11

Lecture 15 - Chromosomal Variations updated slides 06-01-11...

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Chromosomal Variations Makeup slides Please discard the last 6 slides from previous lecture notes Lecture 15 June 2 Chapter 9
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Meiosis of Paracentric Inversion Heterozygote ± 50% gametes are nonviable due to missing some gene copies http://www.youtube.com/watch?v=WYvkuKCut Bs&feature=related
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Meiosis of Pericentric Inversion Heterozygote ± 50% gametes are nonviable due to missing or duplicating of gene copies
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Movement of one part of a chromosome to another chromosome ± Nonreciprocal translocation: no reciprocal exchange, one-way ± Reciprocal translocation: two-way exchange of segments between non-homologous chromosomes Translocation
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Effects of Translocations ± Translocations mostly do not result in a loss of genetic
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Unformatted text preview: material, so they often do not cause detectable changes. But if it takes place within a gene, it will disrupt its function Or sometimes it causes deletions or chromosome lose. e.g. Robertsonia translocation (14/21) Familial Down http://www.youtube.com/watch ?v=WqHEndYJEkQ&NR=1 Meiosis of Translocation heterozygote Individuals that are heterozygous for a reciprocal translocation often have reduced fertility. eight chromatids pairing Three-way segragation Gametes from adjacent-1 or -2 are nonviable due to missing or duplicating gene copies Gametes from alternate segregation are all viable...
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Lecture 15 - Chromosomal Variations updated slides 06-01-11...

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