Lecture_2Paper_1 posting

Lecture_2Paper_1 posting - Paper #1: Regulation of skeletal...

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Paper #1: Regulation of skeletal myogenesis by association of the MEF2 transcription factor with Class II histone deacetylases, Lu, J., McKinsey, T.A., Zhang, C., and Olson, E.N., Molecular Cell, 6:233-244, 2000.
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Final exam on my section: Things you need to study for papers #1-4 1. You should be able to explain any figure in these papers that is shown to you, after being told the method used: •. What was done (no details in the method but should state basic experimental design and background info relevant to the experiment) •. What it means •. Was it done correctly? Was something left out? •. What could you do to improve the experiment?
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Final exam on my section: Things you need to study for papers #1-4 2. You should be able to describe the overall model for each paper: •. Draw the model and explain it •. Explain which experiments supported this model (include the outcome of the experiment so it is clear how this experiment supported the model) •. Suggest other approaches or next step experiments 3. You should understand what each technique is used for and extrapolate this into new situations.
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Please note: Marks will not be deducted for wrong answers. Please be as complete as possible and assume the broadest interpretation of the question, not the narrowest. You can use diagrams to aid your explanation but you must also have written words to back up the diagram. Slides marked with a star are important. Final exam for my section: Things you need to study for papers #1-4
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You will not be directly tested on: The general introduction (lecture #1) but this introduction is relevant to the papers that we cover.
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For stem cell therapy lecture (lecture #6): Understand the different types of stem cells Where are they from? What advantage or disadvantage do they have? What experimental evidence is there that they work? Define terms
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Eric Olson Leader in the field of skeletal and cardiac myogenesis (cloned myogenin, MEF2C, showed synergy) Total of 557 papers with 45,685 citations H index = 106 (106 papers published with over 106 citations since 1995) ( From Scopus: http://www.scopus.com)
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Eric Olson Company Myogen sold for $2.5 billion in 2006. Development of medicine for the treatment of heart disease Also sings in a rock band!
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Questions Do Class II HDACs regulate myogenesis? By what mechanism? How is the inhibition regulated?
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Why is it important to understand these questions? 1. We need to understand how chromosome structure affects the regulation of transcription. 2. Understanding how chromatin structure affects transcription during muscle development may enable new approaches for increasing the amount or regulating the amount of muscle obtained for cell therapy.
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Why understand the details of papers rather than just memorizing the model at the end? Being able to understand and critically read
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Lecture_2Paper_1 posting - Paper #1: Regulation of skeletal...

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