7 - Review questions People with beriberi a disease caused...

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Review questions People with b beriberi ` a disease caused by thiamine deficiency, have elevated blood levels of pyruvate and alpha-ketoglutarate, especially after consuming a meal rich in carbohydrates. How are these phenotypic effects related to a deficiency of thiamine? ( i.e., what is the biochemical basis for the increased blood levels of these metabolites?) Thiamine is required for the synthesis of TPP (thiamine pyrophosphate), which is a coenzyme for pyruvate dehydrogenase, and for alpha-ketoglutarate dehydrogenase. Without sufficient TPP the substrates for these enzymes accumulate and increase in the blood. Although oxygen does not participate directly in the cycle, the cycle operates only when O 2 is present. Why? (come to the next lecture!) Oxygen is needed for electron transport chain activity, which oxidizes NADH +H and FADH 2 so that the TCA cycle can continue.
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¢ Midterm 1 is next Wed – please leave coats, books and bags in your lockers, as none will be allowed at your seats. l ~ 30 MCQ; 20 T/F; 15 Fill-in-the-blank l One hour l Not optional; mark of zero without a doctor ` s note l 25% of final mark ¢ Next class (Mon) is our TCA Cycle Song Contest (with prizes), and there will be a short lecture on current metabolic research in the area of Mitochondrial Uncoupling . (There will be 2-3 related questions on the midterm)
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Oxidative Phosphorylation: The Ultimate Energy Transducing System in Cells Lecture 7 BCH 3120 Jan 26, 2011
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The Chemiosmotic Theory: the basis of oxidative phosphorylation l The aspect of the present position of consensus that I find most remarkable and admirable, is the altruism and generosity with which former opponents of the chemiosmotic hypothesis have not only come to accept it but have actively promoted it to the status of a theory z Peter Mitchell, Nobel prize ceremony 1978 l If an idea presents itself to us, we must not simply reject it because it does not agree with the logical deductions of a reigning theory z Claude Bernard, 1813
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What ` s the difference between an hypothesis and a theory? Hypothesis: ¢ from Newton onwards, a theory or suggestion that is still speculative. (Sometimes, even after all reasonable doubt has been dispelled, a theory retains the title of hypothesis. e.g., Avogadro ` s hypothesis) Theory: ¢ A statement that can be proved ( i.e., the conclusion of an argument constructed according to the rules of a system in which there are no premises)
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Lecture Outline ¢ Review of substrate oxidations l Substrate Level vs. Oxidative Phosphorylation ¢ Electron Transport Chain l Importance of Cytochromes and Fe-S proteins ¢ Mitochondrial Shuttles for Reducing Equivalents ¢ Chemiosmotic Theory & Oxidative Phosphorylation l Stoichiometry of ATP Synthesis l Uncoupling of Oxidative Phosphorylation l Inhibitors of Oxidative Phosphorylation ¢ Regulation of Oxidative Phosphorylation
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This note was uploaded on 12/18/2011 for the course BCH 3120 taught by Professor Mary-ellenharper during the Winter '11 term at University of Ottawa.

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7 - Review questions People with beriberi a disease caused...

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