8 - Mitochondrial Uncoupling: Energy Costs and ROS Control...

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Unformatted text preview: Mitochondrial Uncoupling: Energy Costs and ROS Control Benefits Costs Mary-Ellen Harper, PhD Mary-Ellen Professor Professor Department of Biochemistry, Microbiology and Immunology University of Ottawa, Canada Summary Summary UCP2 and UCP2 decrease mitochondrial ROS UCP2 production production • by decreasing protonmotive force and by increasing basal/resting oxygen consumption increasing • activated by ROS (thus a ‘negative feedback negative loop’) loop • protein glutathionylation may be the on/off protein switch switch • implications for signaling (insulin secretion; satiety signaling in the brain…) and oxidative stress. stress. ...
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This note was uploaded on 12/18/2011 for the course BCH 3120 taught by Professor Mary-ellenharper during the Winter '11 term at University of Ottawa.

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