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Unformatted text preview: Mitochondrial Uncoupling: Energy
Costs and ROS Control Benefits
Costs Mary-Ellen Harper, PhD
Department of Biochemistry, Microbiology and Immunology
University of Ottawa, Canada Summary
UCP2 and UCP2 decrease mitochondrial ROS
by decreasing protonmotive force and
increasing basal/resting oxygen consumption
activated by ROS (thus a ‘negative feedback
protein glutathionylation may be the on/off
implications for signaling (insulin secretion;
satiety signaling in the brain…) and oxidative
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This note was uploaded on 12/18/2011 for the course BCH 3120 taught by Professor Mary-ellenharper during the Winter '11 term at University of Ottawa.
- Winter '11