{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

8 - Mitochondrial Uncoupling Energy Costs and ROS Control...

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Mitochondrial Uncoupling: Energy Costs and ROS Control Benefits Costs Mary-Ellen Harper, PhD Mary-Ellen Professor Professor Department of Biochemistry, Microbiology and Immunology University of Ottawa, Canada Summary Summary UCP2 and UCP2 decrease mitochondrial ROS UCP2 production production • by decreasing protonmotive force and by increasing basal/resting oxygen consumption increasing • activated by ROS (thus a ‘negative feedback negative loop’) loop • protein glutathionylation may be the on/off protein switch switch • implications for signaling (insulin secretion; satiety signaling in the brain…) and oxidative stress. stress. ...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern