10 - BCH 3120 lipid and amino acid metabolism zemin yao...

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zemin yao professor and chair e-mail: [email protected] BCH 3120 lipid and amino acid metabolism 02-19-11, Wed. 08:30-10:00 08:30-10:00 am
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course outline 02-09-11, Wed fatty acid β oxidation 02-14-11, Mon ketogenesis and fatty acid synthesis 02-16-11, Wed triacylglycerol and phospholipid synthesis uOttawa reading break 02-28-11, Mon biosynthesis of cholesterol 03-02-11, Wed lipoprotein metabolism 03-07-11, Mon regulation of cholesterol homeostasis 03-09-11, Wed amino acid deamination and the urea cycle 03-14-11, Mon biosynthesis of amino acids and related molecules 03-16-11, Wed regulation of amino acid metabolism 03-21-11, Mon midterm
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lipid metabolism - objectives to familiarize with major lipid synthetic & degradative pathways and their compartmentalization in mammalian cells to understand the biological significance of these metabolic pathways to appreciate how various lipid metabolic pathways are regulated under different conditions
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fatty acid β oxidation β oxidation in mitochondria β oxidation of unsaturated fatty acids β oxidation in peroxisome
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let’s review structure and nomenclature of fatty acids HO e.g. oleic acid (18:1 9 ) O O HO trans cis α β 1 5 4 3 2 10 8 9 7 6 12 13 14 15 16 17 18 11 naturally occurring ϖ
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O HO 18 14 15 16 17 9 11 10 12 13 7 6 5 4 3 2 1 8 e.g. oleic acid [18:1(n-9) or 18:1( ϖ -9)] an alternative nomenclature of fatty acids ϖ
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O HO 3 7 6 5 4 12 10 11 9 8 14 15 16 17 18 19 20 13 2 1 EPA (eicosapentaenoic acid) 20:5 5 , 8 , 11 , 14 , 17 20:5(n-3) or 20:5( ϖ -3) O HO 18 14 15 16 17 9 11 10 12 13 7 6 5 4 3 2 1 8 19 20 ϖ
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fatty acid β oxidation β oxidation in mitochondria β oxidation of unsaturated fatty acids β oxidation in peroxisome
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fatty acid β oxidation in mitochondria fatty acid activation – formation of acyl-CoA transport of acyl-CoA into mitochondrion β oxidation within the mitochondrial matrix
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matrix outer membrane inner membrane acyl-CoA synthetase HSCoA + ATP AMP + 2Pi acyl-CoA fatty acid activation of fatty acids – formation of fatty acyl-CoA cytosol
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palmitic acid (16:0) HSCoA + palmitoyl-CoA (C 13 ) - CH 2 - CH 2 - C - S - CoA α β thioesters – activated fatty acyl chains O
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energy required to activate a fatty acid molecule fatty acid + HS-CoA acyl-CoA ATP AMP + Pi + Pi 2 high energy bonds are required = 2 ATP equivalent
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1. at lease five (5) ACS fund in rat liver, heart and kidney three (3) acting on short chain FAs (<C 8 ) – mitochondrial matrix two (2) acting on medium (C 8 -C 14 ) and long chain FAs (C 16 -C 20 ) – outer mitochondrial membrane 2. ACS also present on the cytosolic surface of peroxisome membrane
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This note was uploaded on 12/18/2011 for the course BCH 3120 taught by Professor Mary-ellenharper during the Winter '11 term at University of Ottawa.

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10 - BCH 3120 lipid and amino acid metabolism zemin yao...

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