13 - 02-28-11, Mon. 10:00-11:30 10:00-11:30 am zemin yao...

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Unformatted text preview: 02-28-11, Mon. 10:00-11:30 10:00-11:30 am zemin yao professor and chair biochemistry, microbiology & immunology e-mail: zyao@uottawa.ca BCH 3120 lipid and amino acid metabolism ER ACS fatty acid acyl-CoA + G3P GPAT lyso-PA review lecture 12 1. TAG synthesis (de novo) PAP1 DAG AGPAT PA PAP1 (inactive) (active) + acyl-CoA TAG + acyl-CoA DGAT TAG cytosol lumen PAP1: phosphatidic acid phosphohydrolase AGPAT: acylglycerol 3-phosphate acyltransferase GPAT: glycerol 3-phosphate acyltransferase DGAT: diacylglycerol acyltransferase ER PC CT (inactive) CT (active) phosphocholine + CTP CDP-choline DAG CPT PE PEMT PEMT PEMT PDME PMME choline CK review lecture 12 1. PC synthesis ( Kennedy pathway ) CK: choline kinase CT: phosphocholine cytidylyltransferase CPT: CDP-choline:diacylglycerol phosphocholine transferase PEMT: phosphatidylethanolamine methyltransferase phospholipid metabolism glycerophospholipids the Kennedy pathway for PC and PE the PE methylation pathway the base exchange sphingolipids sphingophospholipid - sphingomyelin sphingoglycolipids ceramide is also a precursor for sphingoglycolipid synthesis cerebrosides globosides gangliosides C- CH = CH- (CH 2 ) 12- CH 3 OH R- C- NH- C- H CH 2 OH O ceramide glucose galactose GalNac sialic acid O- O- O- N ER E P M L synthesis of GalCer in ER lumen synthesis of GlcCer on Golgi Golgi G cerebroside synthesis O- O- GlcCer GalCer cGalT cGlcT globoside and ganglioside synthesis GlcCer flippase Golgi lumen globoside synthesis ganglioside synthesis summary: sphingolipid metabolism sphingolipids have the sphingosine backbone sphingomyelin is the only sphingophospholipid that is synthesized in the Golgi apparatus cerebrosides are simple sphingoglycolipids that contain one sugar group, e.g. GlcCer and GalCer globosides and gangliosides are complex sphingoglycolipids that are synthesized in the Golgi lumen and are eventually presented on the cell surface course outline 02-09-11, Wed fatty acid oxidation 02-14-11, Mon ketogenesis and fatty acid synthesis 02-16-11, Wed triacylglycerol and phospholipid synthesis uOttawa reading break 02-28-11, Mon biosynthesis of cholesterol 03-02-11, Wed lipoprotein metabolism 03-07-11, Mon regulation of cholesterol homeostasis 03-09-11, Wed amino acid deamination and the urea cycle 03-14-11, Mon biosynthesis of amino acids and related molecules 03-16-11, Wed regulation of amino acid metabolism 03-21-11, Mon midterm todays lecture biological functions of cholesterol cholesterol synthesis pathway regulation of cholesterol synthesis biological functions of cholesterol 1. structural component of cell membranes, particularly the plasma membranes 2. constituent of lipoproteins 3. precursor for bile acids and steroid hormones caveolae caveolin outside inside plasma membrane lipid raft cholesterol cholesterol is a structural component of cell membranes cholesterol and cholesteryl ester are constituents of lipoproteins cholesteryl ester protein protein cholesterol phospholipid structures of the major bile acids and the...
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13 - 02-28-11, Mon. 10:00-11:30 10:00-11:30 am zemin yao...

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