14 - zemin yao professor and chair biochemistry,...

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Unformatted text preview: zemin yao professor and chair biochemistry, microbiology & immunology e-mail: zyao@uottawa.ca BCH 3120 lipid and amino acid metabolism 03-02-11, Wed. 08:30-10:00 08:30-10:00 am review lecture 13: cholesterol metabolism cholesterol de novo synthesis cell taken up from outside of cells bile acids cholesteryl ester efflux HMG-CoA reductase ACAT cholesterol 7 hydroxylase course outline 02-09-11, Wed fatty acid oxidation 02-14-11, Mon ketogenesis and fatty acid synthesis 02-16-11, Wed triacylglycerol and phospholipid synthesis uOttawa reading break 02-28-11, Mon biosynthesis of cholesterol 03-02-11, Wed lipoprotein metabolism 03-07-11, Mon regulation of cholesterol homeostasis 03-09-11, Wed amino acid deamination and the urea cycle 03-14-11, Mon biosynthesis of amino acids and related molecules 03-16-11, Wed regulation of amino acid metabolism 03-21-11, Mon midterm todays lecture lipoprotein structure and composition lipoprotein function and metabolism lipoprotein receptors lipids exist in various forms in an aqueous solution micelle liposome vesicles microemulsion lipoproteins are microemulsions containing proteins TAG & CE OH cholesterol amphipathic -helical proteins lipoproteins are heterogeneous in lipid and protein composition, buoyancy, and size depending upon their relative lipid compositions, lipoproteins are classified as: TAG-rich lipoproteins cholesterol-rich lipoproteins protein-rich lipoproteins disc-shaped and spherical lipoproteins disk-shaped lipoprotein apolipoprotein spherical lipoprotein apolipoprotein TAG apolipoprotein cholesterol TAG-rich lipoproteins TAG-rich lipoproteins are synthesized in the liver (hepatocytes) and intestine (enterocytes) very low-density lipoproteins (VLDL) - liver chylomicrons - intestine the buoyant density of TAG-rich lipoproteins is less than or close to that of H 2 O VLDL d < 1.006 g/ml chylomicron d < 0.95 g/ml cholesterol-rich lipoproteins cholesterol-rich lipoproteins are formed in the circulation low-density lipoproteins (LDL) in circulation the buoyant density of cholesterol-rich lipoproteins is greater than that of H 2 O LDL d = 1.006 1.063 g/ml protein-rich lipoproteins protein-rich lipoproteins are formed in the circulation as well as synthesized in the liver high-density lipoproteins (HDL) - in circulation HDL - liver the buoyant density of protein-rich lipoproteins is much greater than that of H 2 O HDL - d = 1.063 1.21 g/ml separation of lipoproteins on the basis of their buoyant density VLDL LDL HDL VLDL (30-80 nm) LDL (18-25 nm) HDL (5-12 nm) electron-microscopy of plasma lipoproteins fasting samples chylomicrons (75-120 nm) postprandial samples composition of major plasma lipoproteins VLDL LDL HDL protein 5-10 20-25 40-55 TAG PL CE chol 50-65 15-20 10-15 5-10 7-10 15-20 35-40 7-10 3-5 20-35 12 3-4 TAG, triacylglycerol; PL, phospholipid; CE, cholesteryl ester chylomicrons...
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14 - zemin yao professor and chair biochemistry,...

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