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14 - BCH 3120 lipid and amino acid metabolism zemin yao...

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zemin yao professor and chair biochemistry, microbiology & immunology e-mail: [email protected] BCH 3120 lipid and amino acid metabolism 03-02-11, Wed. 08:30-10:00 08:30-10:00 am
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review lecture 13: cholesterol metabolism cholesterol de novo synthesis cell taken up from outside of cells bile acids cholesteryl ester efflux HMG-CoA reductase ACAT cholesterol 7 α hydroxylase
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course outline 02-09-11, Wed fatty acid β oxidation 02-14-11, Mon ketogenesis and fatty acid synthesis 02-16-11, Wed triacylglycerol and phospholipid synthesis uOttawa reading break 02-28-11, Mon biosynthesis of cholesterol 03-02-11, Wed lipoprotein metabolism 03-07-11, Mon regulation of cholesterol homeostasis 03-09-11, Wed amino acid deamination and the urea cycle 03-14-11, Mon biosynthesis of amino acids and related molecules 03-16-11, Wed regulation of amino acid metabolism 03-21-11, Mon midterm
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today’s lecture lipoprotein structure and composition lipoprotein function and metabolism lipoprotein receptors
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lipids exist in various forms in an aqueous solution micelle liposome vesicles microemulsion
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lipoproteins are microemulsions containing proteins TAG & CE OH cholesterol amphipathic α -helical proteins lipoproteins are heterogeneous in lipid and protein composition, buoyancy, and size depending upon their relative lipid compositions, lipoproteins are classified as: TAG-rich lipoproteins cholesterol-rich lipoproteins protein-rich lipoproteins
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disc-shaped and spherical lipoproteins disk-shaped lipoprotein apolipoprotein spherical lipoprotein apolipoprotein TAG apolipoprotein cholesterol
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TAG-rich lipoproteins TAG-rich lipoproteins are synthesized in the liver (hepatocytes) and intestine (enterocytes) very low-density lipoproteins (VLDL) - liver chylomicrons - intestine the buoyant density of TAG-rich lipoproteins is less than or close to that of H 2 O VLDL – d < 1.006 g/ml chylomicron – d < 0.95 g/ml
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cholesterol-rich lipoproteins cholesterol-rich lipoproteins are formed in the circulation low-density lipoproteins (LDL) – in circulation the buoyant density of cholesterol-rich lipoproteins is greater than that of H 2 O LDL – d = 1.006 – 1.063 g/ml
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protein-rich lipoproteins protein-rich lipoproteins are formed in the circulation as well as synthesized in the liver high-density lipoproteins (HDL) - in circulation HDL - liver the buoyant density of protein-rich lipoproteins is much greater than that of H 2 O HDL - d = 1.063 – 1.21 g/ml
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separation of lipoproteins on the basis of their buoyant density VLDL LDL HDL
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VLDL (30-80 nm) LDL (18-25 nm) HDL (5-12 nm) electron-microscopy of plasma lipoproteins fasting samples chylomicrons (75-120 nm) postprandial samples
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composition of major plasma lipoproteins VLDL LDL HDL protein 5-10 20-25 40-55 TAG PL CE chol 50-65 15-20 10-15 5-10 7-10 15-20 35-40 7-10 3-5 20-35 12 3-4 TAG, triacylglycerol; PL, phospholipid; CE, cholesteryl ester chylomicrons lipoprotein composition (wt %) 1.2-2.5 7-9 1-3 3-5 84-89 d (g/ml) <0.95 <1.006 1.006-1.063 1.063-1.21
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the proteins associated with lipoproteins are called apolipoproteins
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