18 - BCH 3120 lipid and amino acid metabolism zemin yao...

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zemin yao professor and chair e-mail: zyao@uottawa.ca BCH 3120 lipid and amino acid metabolism 03-16-11, Wed. 8:30-10:00 8:30-10:00 am
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review lecture 17 – synthesis of non- essential amino acids precursors utilized for non-essential amino acid synthesis are derived primarily from glycolysis or the TCA cycle transamination of amidation are the major biochemical reactions involved in amino acid synthesis glutamate is the major amino group donor in transamination reactions
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02-09-11, Wed fatty acid β oxidation 02-14-11, Mon ketogenesis and fatty acid synthesis 02-16-11, Wed triacylglycerol and phospholipid synthesis uOttawa reading break 02-28-11, Mon biosynthesis of cholesterol 03-02-11, Wed lipoprotein metabolism 03-07-11, Mon regulation of cholesterol homeostasis 03-09-11, Wed amino acid deamination and the urea cycle 03-14-11, Mon biosynthesis of amino acids and related molecules 03-16-11, Wed regulation of amino acid metabolism 03-21-11, Mon midterm course outline
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today’s lecture SAM as methyl donor in methylation reactions amino acid and their derivative as neurotransmitters regulation of amino acid synthesis review of amino acid metabolism
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one-carbon unit transfer biotin – transfer CO 2 (e.g. caboxylase) tetrahydrofolate – transfer CH or CH 2 (lecture 19) S -adenosylmethionine – transfer CH 3 cofactors involved in transfer of one-carbon groups
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three co-factors involved in C transfer biotin methionine adenosine SAM folate
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methionine adenosyl transferase catalyzes SAM synthesis condensation at 5’ carbon of ribose
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SAM is the major methyl donor in many transmethylation reactions > 40 metabolic reactions requires SAM for methyl transfer lipids (e.g. PE-to-PC) proteins nucleic acids
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S -adenosylhomocysteine is broken down to homocysteine
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homocysteine acquires a methyl group from folate to form methionine methionine synthase folate is the methyl donor B12 is a co-enzyme
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summary - activated-methyl cycle
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summary - activated-methyl cycle S -adenosylmethionine and S -adenosylhomocysteine cycle is an important mechanism for one-carbon unit metabolism many biochemical reactions (lipid, protein, nucleic acid) utilize S - adenosylmethionine as methyl-group donor abnormal homocysteine metabolism is implicated in cardiovascular diseases
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18 - BCH 3120 lipid and amino acid metabolism zemin yao...

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