PROPLEM ST - Folic acid DHF 3. What happens if you’re B12...

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Problem set 1 1C metabolism, purine synthesis and methyl trap
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When things go wrong. ..dysregulation of 1C metabolism and purine synthesis The goal of these problems is NOT to have you memorize and regurgitate the pathways! Use the biochemical pathways as a TOOL to APPLY the concepts that you’ve learned. Deduce your answers ONE step at a time Use the pathway diagrams (provided here as a starter, as well as those in the lecture and the textbook) and your knowledge of regulatory mechanisms used in purine synthesis to answer the questions
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? 1. What happens in individuals that are HGPRT deficient? X Purine salvage pathway
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2. What happens in individuals that are adenosine deaminase deficient? X deoxy ?
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MacFarlane A J et al. J. Biol. Chem. 2009;284:1533-1539 ©2009 by American Society for Biochemistry and Molecular Biology
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Unformatted text preview: Folic acid DHF 3. What happens if you’re B12 deficient? How would taking a folic acid supplement affect the outcome? *Circulating folate is 5-methylTHF and cells must convert it FIRST before it can be used for other parts of the pathway DHFR What happens if you’re B12 deficient? Immediate effect? 5-methylTHF from circulation THF What happens if you’re B12 deficient? Overall effect? MacFarlane A J et al. J. Biol. Chem. 2009;284:1533-1539 ©2009 by American Society for Biochemistry and Molecular Biology Folic acid DHF How would taking a folic acid supplement affect the outcome? *Keep in mind that circulating folate is 5-methylTHF and that cells must convert it FIRST before it can be used for the other parts of the pathway DHFR...
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This note was uploaded on 12/18/2011 for the course BCH 3120 taught by Professor Mary-ellenharper during the Winter '11 term at University of Ottawa.

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PROPLEM ST - Folic acid DHF 3. What happens if you’re B12...

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