LEC21 - Interdisciplinary School of Health Sciences Faculty...

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Interdisciplinary School of Health Sciences Faculty of Health Sciences University of Ottawa HSS 2101 B Health Problems (3 credits) Professor: Dr. Karen Phillips Office Hours: Templeton Room 215, Tuesdays 1:00-2:20pm After end of classes office hours will be moved to different date.
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Date Topic Tuesday, March 1 14. Diseases/Disorders of the Gastrointestinal Tract Chapter 9 Friday, March 4 15. Cardiovascular Disease I Chapter 6 Tuesday, March 8 16. Cardiovascular Disease II Chapter 7 Friday, March 11 17. Respiratory Disease Chapter 8 Tuesday, March 15 18. Pathology of the Reproductive System- Chapter 11 (Assignment Due 5%) Friday, March 18 19. Diseases Associated with Pregnancy Chapter 12 Tuesday, March 22 20. Renal Pathology Chapter 10 CLASS EVAL. Friday, March 25 21. Diabetes Chapter 12 Tuesday, March 29 22. Diseases of the Endocrine System Chapter 12 Friday, April 1 23. Pathology of the Nervous System I Chapter 13 Tuesday, April 5 24. Pathology of the Nervous System II Chapter 13 Friday, April 8 REVIEW Final Exam Lectures 14-24; 45%
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Hormones of the Pancreas several hundred thousand clusters of cells- islets of Langerhans four types of cells: beta cells, which secrete insulin alpha cells, which secrete glucagon; delta cells, which secrete somatostatin, and gamma cells, which secrete a polypeptide of unknown function
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As food is digested glucose enters the bloodstream insulin released glucose taken up to muscle, liver, fat Diabetic patients- have high blood glucose Blood Glucose Regulation Blood Glucose Regulation
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Blood Glucose Regulation Blood Glucose Regulation
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Beta Cells produce insulin –required for glucose homeostasis Contain glut2 transporters which transport glucose from blood into beta cell Glucose triggers intracellular events which result in insulin secretion Trigger for insulin secretion from beta cells: rising level of circulating glucose ("blood sugar").
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Insulin Peptide hormone Synthesized as inactive pro- hormone binds insulin receptor: transmembrane protein receptor expressed by responding cells (liver, skeletal muscle, fat cells)
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Liver Muscle Adipose tissue Insulin + glycogen synthesis + glucose uptake + glucose uptake + glycolysis + amino acid uptake + free fatty acid uptake - glycogenolysis - proteolysis - lipolysis - gluconeogenesis - ketogenesis Glucagon + glycogenolysis minimal action minimal action + gluconeogenesis + ketogenesis Insulin and Glucagon
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Major types of diabetes: Diabetes Mellitus 1.Type I diabetes (insulin dependent diabetes mellitus) 2.Type II diabetes (insulin in dependent or insulin resistant diabetes mellitus ) 3.Gestational diabetes endocrine disorder, signs and symptoms: Glucose in urine Increased volume of urine (osmotic effects) increased blood glucose levels diabetes insipidus : different disease; produces large volume of urine ADH deficiency, unrelated to glucose homeostasis
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Diabetes Mellitus Diabetes Mellitus
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This note was uploaded on 12/18/2011 for the course HSS 2101 taught by Professor Karenphillips during the Fall '11 term at University of Ottawa.

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LEC21 - Interdisciplinary School of Health Sciences Faculty...

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