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Lecture 4 - Biopsychogical Method Lecture 5 Chapter 5 Steps...

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Biopsychogical Method 1/30/08 Lecture 5 Chapter 5 Steps in NT Release Example of metabotropic receptor: o Autoreceptors: metabotropic receptors on presynaptic button that bind own NT and regulate NT levels in synapse. o NT are finally deactivated in the synapse via: Enzymes (eg. Aetlycholinesterase) Reuptake (most common, recycled) Drugs and Synaptic Transmission Agonists vs Antagonists o Agnosists enhance/facilitate particular drug effects o Antagonists: inhibit particular NT effects Ie. Agnoists :cocaine –increase activity of Dopamine and Norepinephrine, blocks reuptake Antagonists: Atropine: extract of belladonna plant; given to dilate pupils before eye exam o Ach receptor blocker o Binds to one type of ach receptor o Many muscarinic receptors in brain- also disrupts memory Curare: plant extract ; used as paralyzing agent in surgeries o Ach receptor blocker o Nicotinic receptors are located at Nueromuscular junctions Deadly, used only at specific sites Paralitic agents Sterotaxic Surgery Means of positionsing electrodes or tube inside specific brain area Uses stereotaxic atlas (brain structure map) and streotaxic insutrument Moves in 3 planes: dorsal ventral, anterior posterior, medial lateral Disrupt normal activities in the brain by legioning certain areas. o Steps of surgery BRAIN LEGION READ TEXT BOOK Cell stimulation: stimulate area behavioral effects (eating moving etc) Record from cells: eg. Rat in maze, monitor brain cell activity, can do In vivo (in organism) or In vitro(in a dish) Penfield o Pioneering neurosurgeon in the 1940s.
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