Lecture 9 Diabetes

Lecture 9 Diabetes - Lecture 9 Diabetes Role of Insulin in...

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Lecture 9: Diabetes
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Role of Insulin in Muscle Tissue 1. Insulin attaches to insulin receptors 2. Transports glucose into the cell - also amino acids and fatty acids 3. Also stimulates the synthesis of glycogen a. 400 g muscle b. 100 g in liver 4. Stimulates the synthesis of fat from glucose 5. Number and sensitivity of muscle insulin receptors is dependent upon movement! glycogen glycogen
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Role of Insulin on Adipose Cells Fat Droplet Membrane Nucleus 1. Insulin attaches to insulin receptors 2. Transport glucose and fatty acids into the cell 3. Stimulates the synthesis of fat from glucose 4. Stimulates lipoprotein lipase 5. Blocks action of hormone sensitive lipase 6. Blocks sympathetic receptors 7. Number and sensitivity of insulin and sympathetic receptors is dependent upon size of the adipose cell! hormone sensitive lipase VLDL Lipoprotein lipase
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1. Increases nutrient uptake 2. Increases glycogen synthesis 3. Increases fat synthesis 4. Movement increases sensitivity of insulin receptors Muscle 1. Increases nutrient uptake 2. Increases fat synthesis 3. Activates Lipoprotein Lipase 4. Reducing size of cell increases sensitivity of insulin receptors Adipose REVIEW Insulin
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Effect of Insulin in Liver 1. Transport of glucose not insulin dependent a. Like neural tissue 2. Stimulates synthesis of glycogen 3. Stimulates triglyceride synthesis 4. Stops the synthesis of glucose (gluconeogenesis) glycogen fat
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Glucose SUMMARY
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Glucose Liver SUMMARY
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Glucose glycogen fat Liver SUMMARY
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Glucose glycogen fat blood Liver SUMMARY
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Glucose glycogen fat blood Liver pancreas SUMMARY
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Glucose glycogen fat blood Liver pancreas beta cells SUMMARY
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Glucose glycogen fat blood Liver pancreas beta cells insulin SUMMARY
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Glucose glycogen fat blood Liver pancreas beta cells insulin adipose or muscle SUMMARY
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Glucose glycogen fat blood Liver pancreas beta cells insulin adipose or muscle receptors SUMMARY
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Glucose glycogen fat blood Liver pancreas beta cells insulin adipose or muscle glycogen or fat SUMMARY
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Lecture 9 Diabetes - Lecture 9 Diabetes Role of Insulin in...

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