Hemophilia - to the throne, had hemophilia. The Czar's...

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Hemophilia People with hemophilia lack a clotting factor in their blood and as a result, their blood does not form clots normally. This results in excessive bleeding from even minor cuts. Internal hemorrhaging from bruises is common and leads to painful complications. The incidence is in 1,500 newborn males. Most (75%) have hemophilia A, a lack of clotting factor VIII. Hemophilia B- "Christmas Disease" is a defect in clotting factor IX. Transfusions of fresh whole blood or plasma or factor concentrates control bleeding but have previously caused AIDS infections. The human gene has been isolated and cloned using recombinant DNA techniques. This is leading to improved treatment. Royal Families of Europe Victoria (granddaughter of George III) was a carrier and spread the gene to the royal families of Europe. Her granddaughter Alix- married Czar Nicholas II of Russia. The Czar’s son Alexis, heir
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Unformatted text preview: to the throne, had hemophilia. The Czar's preoccupation with Alexis' health contributed to the revolution that overthrew the throne and eventually led to the communist government. Duchenne Muscular Dystrophy There are four different kinds of X-linked muscular dystrophy. They are multiple alleles at a single locus. Duchenne’s is the most common and most severe form of muscular dystrophy. 1 in 5,000 live male births (Duchenne’s) One in 4000 newborn males have some form of muscular dystrophy. One third of these are new mutations. Muscular deterioration begins between ages 3 to 5. Affected individuals are confined to a wheelchair by age12 and rarely survive past age 20. Death is usually due to breathing or heart problems. It is transmitted primarily by female carriers (males rarely reproduce)...
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This note was uploaded on 12/15/2011 for the course BIO BSC1010 taught by Professor Gwenhauner during the Fall '10 term at Broward College.

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