{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Tumor - If the DNA cannot be repaired the p53 protein...

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Tumor-Suppressor Genes Damaged or mutated DNA may result in uncontrolled cell growth. Proteins produced by some tumor-suppressor genes stop the cell cycle when DNA becomes damaged. If the DNA cannot be repaired, these proteins cause the cell to kill itself (called apoptosis ). For example, a peeling sunburn is due to apoptosis. The DNA has become too badly damaged to be repaired, so the cells kill themselves. This prevents cancer from developing from the mutations. A tumor-suppressor gene called p53 stops the cell cycle when damage has occurred to DNA and it stimulates repair enzymes to repair the DNA. It produces a protein that combines with the cyclin-kinase complex and inactivates it, thus preventing the cell from dividing.
Image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: If the DNA cannot be repaired, the p53 protein stimulates apoptosis. When tumor-suppressor genes don't function properly, they may not be able to prevent abnormal cell division in mutated cells and the result could be cancer. The most frequent cause of new cancer is a mutation in the p53 gene. It is involved in an estimated 60% of all cancers including cancers of the breast, lung, liver, skin, prostate, bladder, cervix, and colon. Breast cancer prognosis is associated with a tumor suppressor gene called p27. Many cancers are the result of tumor suppressor genes that have become "turned off" so that they do not function properly. Therapies are being developed to turn these genes back on....
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern