Chapter 16 September 9

Chapter 16 September 9 - Limited to aryl alkyl ketones Not...

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1 Friedel­Crafts Acylation: Formation of Phenyl propyl ketone: Mechanism: Generation of the Electrophile: . Reaction of an acid chloride with an aromatic ring
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2 Primary Differences Between F­C Alkylation and Acylation: Additional Functional Group Transformations: No overacylation observed only single substitutions The ring is deactivated by the electron withdrawing carbonyl containing group Reduction of Aryl Alkyl Ketones
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Unformatted text preview: Limited to aryl alkyl ketones Not compatible with nitro groups 3 Clemmensen Reduction (aryl­alkyl ketone): Wolff­Kishner Reduction: 4 Gattermann­Koch Formylation: 5 Substituent Effects in Substituted Aromatic Rings Substituent groups influence the overall reactivity of the aromatic ring Substituents affect the orientation (location) of aromatic ring substitution (O,M,P)...
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This note was uploaded on 12/20/2011 for the course CHEM 234-54 taught by Professor Morrison during the Fall '09 term at UGA.

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Chapter 16 September 9 - Limited to aryl alkyl ketones Not...

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