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Unformatted text preview: we have discussed the last two weeks (much of this chemistry was developed for this purpose). A very nice example is Evans synthesis of ionomycin ( JACS , 1990 , 112 , 5290). Look up this paper and analysis the total synthesis. Provide a complete retrosynthetic analysis (note, copying Evans directly from the paper will win you no points I want more detail), and find all examples of protection/deprotection, alcohol/ketone oxidations and chiral. aux. asym. alkylations or substrate controlled alkylation, and aldol reactions. For the alkylation and aldol reactions, draw a transition state model for each reaction to explain observed stereochemistry. You may have to do more background reading for some of the aux. methods we did not discuss....
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- Fall '08
- Organic chemistry