Autoimmunity for 4th year 2008

Autoimmunity for 4th year 2008 - AUTOIMMUNITY Prof. Emad A...

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Unformatted text preview: AUTOIMMUNITY Prof. Emad A Koshak Professor and Consultant Internal Medicine, Allergy & Immunology King Abdulaziz University- Faculty of Medicine The immune system normally acquires self tolerance by clonal deletion of autoreactive T cells in the thymus before birth and by functional suppression of autoreactive T and B cells at later stages of development. The immune system normally acquires self tolerance by clonal deletion of autoreactive T cells in the thymus before birth and by functional suppression of autoreactive T and B cells at later stages of development. Background on inflammation Background on inflammation The word inflammation literally means "burning." Inflammation occurs in response to a range of traumas from sunburn and wounds, to infection and auto-immune conditions. Whatever the cause, this process is basically the same.... Inflammation occurs in response to a range of traumas from sunburn and wounds, to infection and auto-immune conditions. Whatever the cause, this process is basically the same.... SHARP SHARP Pain Swelling Heat Redness Heat and redness result from dilation of the small blood vessels in the injured area and increased local blood flow. Because blood vessels become more permeable during inflammation, protein rich exudate escapes from blood plasma to the damaged tissue and causes swelling. Pain is believed to result from such chemical substances as serotonin, specific cytokines or from tension of tissue over the inflamed area. Autoimmune disorders are a diverse group of conditions, which occur due to abnormal stimulation and signaling within the immune system. "Self" versus "non-self" recognition is altered. Autoimmune disorders are a diverse group of conditions, which occur due to abnormal stimulation and signaling within the immune system. "Self" versus "non-self" recognition is altered. An autoimmune response occurs because, for some reason, helper T cells recognize a cell of the body (or self cell) as foreign, and mark it for destruction. Examples of Autoimmune Diseases: Multiple sclerosis Myasthenia gravis (acetylcholine receptor autoantibodies) Autoimmune neuropathies such as Guillain-Barr Autoimmune uveitis Nervous System: Nervous System: Gastrointestinal System: Gastrointestinal System: Crohn's Disease Ulcerative colitis Primary biliary cirrhosis Autoimmune hepatitis Blood:...
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Autoimmunity for 4th year 2008 - AUTOIMMUNITY Prof. Emad A...

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