CFT - PRACTICAL 18: COMPLEMENT FIXATION TEST Sayeed Ismail...

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PRACTICAL 18: COMPLEMENT FIXATION TEST Sayeed Ismail Khatib Lecturer Ibn Sina National College for Medical Studies
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Introduction: The complement fixation test (CFT) was extensively used in syphilis serology after being introduced by Wasserman in 1909. Complement is a protein (globulin) present in normal serum. Whole complement system is made up of nine components: C1 to C9 Complement proteins are heat labile and are destroyed by heating at 56°C for 20 – 30 minutes. Complement binds to Ag-Ab complex When the Ag is an RBC it causes lysis of RBC’s.
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Principle Complement takes part in many of the immunological reactions. It gets absorbed during the combination of antigens and antibody. This property of antigen–antibody complex to fix the complement is used in complement fixation test for the identification of specific antibodies. The haemolytic system
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This note was uploaded on 12/21/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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CFT - PRACTICAL 18: COMPLEMENT FIXATION TEST Sayeed Ismail...

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