Consequences_of_Vitamin_D_deficiency_&_Excess_for_intranet

Consequences_of_Vitamin_D_deficiency_&_Excess_for_intranet

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Consequences of Vitamin D By: Prof. M. Y. JAN
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Hypervitaminosis D DEFINITION: A disorder due to the excessive ingestion of Vitamin D resulting in neurologic, gastrointestinal, and renal manifestations. Alternative Name: Vitamin D Toxicity EPIDEMIOLOGY: incidence: ? age of onset: any risk factors: patients on vitamin D for chronic hyperphosphatemic states
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Hypervitaminosis D Pathogenesis 1. Chronic Hypervitaminosis may occur after the ingestion of excessive amounts of vitamin D over weeks (>500 ug/d) or months (>45 ug/d) may lead to (malignant) calcification of soft tissues: heart - aortic valvular stenosis blood vessels - hypertension renal tubules - nephrocalcinosis -> secondary nephrogenic DI -> polyuria, polydipsia; stomach - anorexia, nausea and vomiting, etc
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Hypervitaminosis D CLINICAL FEATURES: Neurological Manifestations hypotonia irritability Gastrointestinal Manifestations anorexia with weight loss constipation or diarrhea nausea and vomiting Renal Manifestations polydipsia polyuria/nocturia +/- dehydration Ocular Manifestations conjunctiva - clouding cornea – clouding retinopathy
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Hypervitaminosis D Other Manifestations aortic valvular stenosis hypertension pallor Fanconi Syndrome episodes of vomiting, dehydration, weakness, and unexplained fever; anorexia, constipation; polydipsia, polyuria; failure to thrive; growth failure; rickets
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Consequences_of_Vitamin_D_deficiency_&_Excess_for_intranet

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