cushing_clear - Background Cushing syndrome is caused by...

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Background Cushing syndrome is caused by prolonged exposure to elevated levels of either endogenous glucocorticoids or exogenous glucocorticoids
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Cushing Syndrome… Individuals often complain of proximal muscle weakness, easy bruising, weight gain, hirsutism , and, in children, growth retardation . Hypertension , osteopenia, diabetes mellitus , and impaired immune function may occur.
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Cushing Syndrome… Pathophysiology Excess levels of either exogenously administrated glucocorticoids or endogenous overproduction of cortisol causes Cushing syndrome. Endogenous glucocorticoid overproduction or hypercortisolism that is independent of adrenocorticotropic hormone (ACTH) is usually due to a primary adrenocortical neoplasm (usually an adenoma but rarely a carcinoma). Bilateral micronodular hyperplasia and macronodular hyperplasia are rare causes of Cushing syndrome.
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Cushing Syndrome… ACTH-secreting neoplasms cause ACTH- dependent Cushing syndrome. They usually are due to an anterior pituitary tumor, that is, classic Cushing disease (80%). Non-pituitary ectopic sources of ACTH, such
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cushing_clear - Background Cushing syndrome is caused by...

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