Diabetes mellitus Mini-med School-1

Diabetes mellitus Mini-med School-1 - Diabetes mellitus...

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Diabetes mellitus Diabetes mellitus McMaster Mini-Med School March 17, 2004 Dr. William Harper Assistant Professor of Medicine, McMaster University. Endocrinologist, Hamilton General Hospital www.drharper.ca
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Diabetes Mellitus Diabetes Mellitus Type 1, IDDM, Juvenile-onset Type 2, NIDDM, Adult-onset The pancreas!
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Type 1 v.s. Type 2 Diabetes Type 1 v.s. Type 2 Diabetes Type 1 DM (< 10%) Type 2 DM (> 90%) Age of onset < 40 > 40 DKA Yes No Weight Usually lean 80% overweight Cause Autoimmune or unknown No autoimmune markers
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Pathophysiology of T1DM Pathophysiology of T1DM antibodies attack islets!
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Pathophysiology of T2DM Pathophysiology of T2DM Blood glucose diet Hepatic glucose output INSULIN Peripheral Tissue Uptake + _
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Natural History of Type 2 Diabetes Natural History of Type 2 Diabetes Normal Impaired glucose tolerance Type 2 diabetes Time Insulin resistance Insulin production Glucose level β -cell dysfunction
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Rising DM Prevalence ( Rising DM Prevalence ( Diagnosed Diagnosed ) ) 0 50 100 150 200 250 300 N (millions) 1995 2000 2025 Developed World Developing World Whole World 5.9 6.2 7.6 3.3 3.5 4.9 4.0 4.2 5.4 (Decimal Numbers = Percent of the population affected)
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Why is the prevalence of Type 2 Diabetes mellitus increasing? Diabetes mellitus increasing?
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This note was uploaded on 12/21/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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Diabetes mellitus Mini-med School-1 - Diabetes mellitus...

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