Diabetes_Type_I_for_intranet

Diabetes_Type_I_for_intranet - Prof M.Y.Jan Diabetes Type I...

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Prof. M.Y.Jan
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Diabetes Type I Different presentations of Diabetes Type I Majority have a classical history of polyuria,  polydipsia, weight loss, lethargy over 4-8 weeks  which if not diagnosed would proceed to Diabetic  Ketoacidosis  Occasionally, especially in the very young there is a  catastrophic onset over 1-2 days with virtually no  preceding history  Occasionally there is a history of slowly but  progressive increasing polyuria and other symptoms (? 
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Age groups Each age group in childhood is not equally affected there is a peak at 10-12 years with a reduction in incidence into adulthood ? subpeak at age 4-5 years Recent epidemiological data suggests that the incidence in the <5 year group is rising Many countries demonstrate a rising incidence
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high incidence of HLA DR 3/4, DQ B1 and DQ A1 islet cell antibodies (ICA) insulin autoantibodies (IAA) antibodies to GAD 65 (glutamic acid decarboxylase) evidence of T-cell reactivity to pancreatic islet cell antigens. autoimmune markers differ in the various
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Diabetes_Type_I_for_intranet - Prof M.Y.Jan Diabetes Type I...

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