effect_of_hyposecretion_growth_hormone_clear

effect_of_hyposecretion_growth_hormone_clear - BY Prof M.Y...

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BY BY : Prof. M.Y. Jan : Prof. M.Y. Jan
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THE GROWTH AXIS Higher CNS centers Hypothalamus Somatostatin GHRH (GH releasing hormone) Pituitary (specific receptors for somatostatin and GHRH ) GH (circulate 30% bound to GH binding protein ) Liver and other Tissues ( specific receptors for GH ) IGF-I IGF-BP Peripheral tissues respond to IGF-I (and to lesser extent to GH directly) mitogenic and metabolic effects IGF-I and IGF-BP IGF-I is a peptide which is GH, nutrition and age dependent plasma level increase during childhood to peak during puberty IGF-I is tightly bound in the plasma, 6 bindings proteins are so far identified IGF-BP 3 is the major carrier protein in plasma and it’s regulation is similar to IGF 1
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GH - Deficiency GHD may result from disruption of the GH axis in the following sites: higher brain hypothalamus or pituitary This dysfunction can be congenital acquired
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Congenital GHD may be associated with: an abnormal pituitary gland be part of a syndrome such as septo-optic dysplasia which may include other pituitary deficiencies, optic nerve hypoplasia, and absence of the septum pellucidum
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Acquired GHD may result from tumor (e.g. Craniopharyngioma) trauma infections
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