GI Carcinoid Tumors - HBazan

GI Carcinoid Tumors - HBazan - GICarcinoidTumors...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
GI Carcinoid Tumors Hernan Bazan, MD Dept. of Surgery 19 April 2005
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
37 yo man with >10 yrs of ankylosing spondylitis  Spine disease HLA B27+ Presented with post-prandial cramps and diarrhea ?IBD Colonoscopy Normal colon TI: Submucosal mass VCE
Background image of page 2
Laparoscopic ileo-colic resection 1/24/05 29 mm EEA end-to-side anastomosis D/C home pod#3 Pathology 1.3 cm submucosal  mass extending into muscularis propria 3/19 LNs positive
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 4
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
1.3cm ileal tumor Submucosal carcinoid tumor, extending into  but  not beyond the muscularis propria All resection margins negative for tumor 3 out of 19 lymph nodes positive for tumor Appendix unremarkable Uninvolved ileal and cecal mucosa  unremarkable
Background image of page 6
Carcinoid Tumors Introduction Majority of carcinoid tumors are slow-growing tumors Carcinoid ”  - Obendorger 1907 – More indolent behavior… Can be treated and often cured, especially in early stages Majority of carcinoid tumors are slow-growing tumors that can be  treated and often cured, especially in early stages. Occurrence of metastasis from carcinoid tumors relates directly to  the size of the primary tumor Lesions < 1 cm rarely metastasize > 2 cm frequently metastasize Classified as neuroendocrine or amine precursor uptake and  decarboxylation tumors
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Small Bowel Carcinoid Tumors Carcinoid tumors may arise from various sites GI tract Appendix Small bowel (Ileum) Rectum Lung Metastasis is related to primary tumor <1 cm: Rarely metastasize >2 cm frequently metastasize Small bowel – Submucosal mass; may be multiple sites
Background image of page 8
Carcinoid Tumors Cellular Classification   No histologic difference between carcinoids  arising in various sites or between  metastasizing and nonmetastasizing lesions Neuroendocrine tumors: Uniform, round, or  polygonal cells Immunohistochemistry: Neuron-specific  enolase (NSE) and chromogranin  Suggests malignancy: cellular pleomorphism,  hyperchromatic nuclei, necrosis, high mitotic 
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

Page1 / 24

GI Carcinoid Tumors - HBazan - GICarcinoidTumors...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online