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Immunogenes or Antigens

Immunogenes or Antigens - ‫بسم اللة...

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Unformatted text preview: ‫بسم اللة الرحمن‬ ‫الرحيم‬ Immunogens Or Antigens Immunogens Or Antigens Immunogens or Antigens Immunogens Immunogen or antigen: * A foreign substance, when introduced into human body, stimulate formation of specific antibodies or sensitized lymphocytes * Antigens have the ability to combine specifically with antibodies produced or sensitized T­lymphocytes induced Immunogens or Antigens Immunogens Haptens: ­ Low molecular weight substances ­ These substances not immunogenic by itself ­ If couple to a larger carrier molecule (albumin, globulins), they become immunogenic ­ Examples : simple chemicals and drugs: penicillin, sulphonamid, aspirin, cosmetic, tranquillizers, neomycin skin ointment Immunogens or Antigens Immunogens Epitopes or Antigenic determinants: * Sites on or within antigen with which antibodies react * Antibodies are specific for epitopes Types of Antigens Types Exogenous Antigens 1­ Bacterial antigens: a­ Antigens related to bacterial cells ­ Somatic antigen (O): part of cell wall gm –ve bacter. ­ Capsular antigen: usually polysaccharide ­ Flagellar Ag (H) : a protein made of flagellin ­ Fimbrial Ag: surface antigens in fimbriated bacilli b­ Antigen secreted by bacteria: ­ Exotoxins ­ Enzymes 2­ Viral antigens: a­ protein coat viral antigens b­ Soluble antigens (soluble nucleoproteins as in influenza) Types Of Antigens Types Endogenous antigens Human tissue antigens: a­ Blood group antigens: A, B and Rh antigens b­ Histocompatibility antigens: Glycoprotein molecules on all nucleotide cells: ­ Major histocompatibility complex antigens (MHC) ­ Human leucocyte antigen (HLA) Major Histocompatibility Complex Antigens (MHC) Antigens * MHC has an important function in presentation of antigens to T­cells * Helper T­cells recognize foreign antigens on surface of APCs, only when these antigens are presented in the groove of MHC II molecule * Cytotoxic T­cells will only recognize antigens, on the surfaces of virus infected cells or tumor cells only when these antigens are presented in the groove of Class I molecule (MHC restriction) Superantigens (SAgs) Superantigens * They activate multiple clones of T­lymphocytes * Bacterial toxins: Staph. aureus toxic shock syndrome toxin (TSST) and enterotoxins Strpt. pyogenes pyrogenic toxin A * They have the ability to bind both class II MHC molecules and TCR β chain * They act as a clamp between the two, providing a signal for T­cell activation Superantigens (SAgs) Superantigens * They are active at very low concentration causing release of large amounts of cytokines * The massive T­cell activation and release of large amounts of cytokines cause systemic toxicity * This method of stimulation is not specific for the pathogen * It does not lead to acquired immunity i.e no memory Antigen Binding And Recognition Molecules Antigen Antigens are recognized by and bind to: 1) B­cell receptors (BCR) : ­ These are membrane­bound immunoglobulins (IgM and IgD) on B­cells ­ BCRs can be secreted in plasma as antibodies 2) T­cell receptors (TCR) ­ α and β chains anchored to T­cells ­ There is a groove which binds small peptides presented by MHC on surface of APCs 3) MHC molecules They are essential for presentation of peptides so that they can be recognized and bind to TCRs Factors influencing Immunogenicty Factors 1­Foreigness : Foreign substances are immunogenic 2­ Molecular size: High molecular weight increase immunogenicty 3­ Chemical structure complexity: High complexity increase immunogenicty 4­ Route of administration: Parenteral routes are more immunogenic to oral route Factors influencing Immunogenicty Factors 5­ Method of administration: a­ Antigen dose: Appropriate dose optimum antigenicty Low dose low­ zone tolerance High dose high­zone tolerance b­ Adjuvant: Substance when injected with an antigen enhance immunogenicty Thanks Thanks ...
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