L10- effects of hypersecretion of GH- white & black

L10- effects of hypersecretion of GH- white & black...

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Effects of hypersecretion of GH Dr. Abdulmoein Eid Al-Agha Assistant Professor & Consultant Pediatric Endocrinologist, King AbdulAziz University & Dr. Erfan Hospital - Jeddah
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Introduction The human adult pituitary weighs approximately 0.5g, not larger than size of a pea, exerts a pivotal role in hormonal regulation of various bodily processes The pituitary gland is responsible for the production of 8 hormones It is largely regulated by the hypothalamus The anterior pituitary accounts for about 75% of its weight
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The pituitary composed of 2 lobes: anterior lobe “ adenohypophysis” posterior lobe “neurohypophysis”
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What is Growth Hormone? (Somatotropin) GH is a protein hormone of 190 amino -acids that is synthesized & secreted by the acidophil cells of the anterior pituitary gland It is a major participant in control of several complex physiologic processes, including The major role of growth hormone in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-I IGF-I stimulates proliferation of chondrocytes (cartilage cells), resulting in bone growth
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IGF-I also appears to be the key player in muscle growth, stimulates both the It also stimulates amino acid uptake and protein synthesis in muscle and other tissues Growth hormone has important effects on Production of growth hormone is modulated by many factors, including stress, exercise, nutrition& deep sleep
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Control of Growth Hormone Secretion It is primary under control of (2 ) hypothalamic hormones & one hormone from the stomach 1.Growth hormone-releasing hormone (GHRH) is a hypothalamic peptide that stimulates both 2.Somatostatin hormone inhibits growth hormone release 3.Ghrelin peptide hormone secreted from the stomach which binds to receptors on somatotroph & potently stimulates secretion of growth hormone
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Effects of GH hypersecretion Gigantism or Acromegaly Acromegaly / Gigantism is a very rare disease (annual incidence: 3/1.000.000) Gigantism results from increased GH secretion during childhood Acromegaly results from overproduction of GH after puberty in adults At puberty, the epiphyseal plates of the long
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L10- effects of hypersecretion of GH- white & black...

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