L22 & L24, addison,CAH & hyperaldestronism

L22&amp L24, - The adrenal gland Abdulmoein E Al-Agha MBBS,DCH,CABP,MRCP(UK Pediatric Endocrinologist Adrenal Gland Adrenal Cortex Zona

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The adrenal gland Abdulmoein E Al-Agha; MBBS,DCH,CABP,MRCP(UK) Pediatric Endocrinologist
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Adrenal Gland
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Adrenal Cortex Zona Glomerulosa mineralocorticoid production, aldosterone Zona Fasciculata glucocorticoid production, cortisol Zona Reticularis androgen production, including testosterone Medulla catecholamines epinephrine and norepinephrine
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Regulation Cortisol
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Regulation of adrenal gland secretion ACTH Cortisol Cortisol
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Aldosterone Mineralocorticoid Regulates concentration of Na+ and K+. Kidney conserves Na+. Kidney excretes K+. Responds to changes in composition of plasma. Linked to renin-angiotensin system of kidney
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Aldosterone Functions
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 Func tio ns  o f the   a ldo s te ro ne  :  Tubular reabsorption of Na + Tubular secretion of K + or H + (Kaliuresis) Increase tubular H + secretion alkalosis” Circulatory function absence of aldosterone secretion EC F volume Blood pressure Plasma Na + K + ANP ↑→ “escape” phenomenon
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Control of Aldosterone ACTH Low Blood Pressure, Low Na+. Juxtaglomerula cells release renin. Renin converts angiotensinogen to angiotensin I. Angiotensin I to angiotensin II by ACE. Angiotensin II stimulates adrenal gland to release aldosterone. Aldosterone acts on kidney.
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Disease States
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   Disease States Addison's disease : Affects about 1 in 100,000 people; caused by adrenal in-sufficiency (90%); typical by auto-immune disorders; both cortisol and aldostertone hormones are lacking. Cushing's disease : Affects about 10 to 15 million people / yr; caused by adrenal hyper-activity (cortisol); typical because of tumor growth exposure to prednisone for asthma, rheumatoid arthritis, lupus or other inflammatory diseases Conn's syndrome : May affect 15% of patients with high blood pressure; caused by hyper production of aldosterone; inability of adrenal cortex to carry out 17 α -hydroxylation; hypertension, loss of potassium in the urine, muscle weakness and passing of large volumes of urine (polyuria)
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Congenital Adrenal Hyperplasia The first case was described in 1865 Family of inherited disorders of adrenal steroidogenesis Each disorder results from a deficiency of one of
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This note was uploaded on 12/21/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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L22&amp L24, - The adrenal gland Abdulmoein E Al-Agha MBBS,DCH,CABP,MRCP(UK Pediatric Endocrinologist Adrenal Gland Adrenal Cortex Zona

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