NBME BONE CARTILAGE REVIEW 2004

NBME BONE CARTILAGE REVIEW 2004 - 1 BONE AND CARTILAGE...

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Unformatted text preview: 1 BONE AND CARTILAGE REVIEW FOR NBME 2004 BONE and CARTILAGE Bone (osteo) vascular mesodermal origin osteoclasts collagen type 1 appositional growth----- compact, cancellous, woven Cartilage (chondro) avascular - diffusion mesodermal origin----- collagen types 1,2 appositional growth interstitial growth hyaline, elastic, fibro 2 Bloom and Fawcett, 1975 HistoTime 3 HistoTime Dr. Gwen Childs THREE CELL TYPES IN BONE OSTEOBLAST OSTEOCYTE OSTEOCLAST (mesenchyme) (mesenchyme) (GM-CFU) Young and Heath, 2000 Young and Heath, 2000 HistoTime HistoTime HistoTime PD 4 OSTEOBLASTS ORIGIN: Mesenchymal precursor cells Osteoprogenitor cells- periosteum- endosteum APPEARANCE: Stellate shape (versus round chondroblasts) Basophilic = prominent RER FUNCTION: Make and mineralize bone-matrix proteins: Type 1 collagen osteocalcin osteopontin osteonectin proteoglycans alkaline phosphatase Use vitamin C when making C ollagen (s C urvy) Become o steocytes (appositional growth) Make factors that stimulate osteoclasts OSTEOCYTES ORIGIN osteoblasts (mesenchymal origin) APPEARANCE stellate (canaliculi, gap junctions) trapped in bone lacunae periosteocytic space = osteocytic osteolysis small golgi and RER (unlike osteoblast) nondividing (unlike chondrocytes) FUNCTIONS osteocytic osteolysis (plasma [Ca ++ ]) mechanotransduction (factors that recruit preosteoblasts) 5 OSTEOCLASTS ORIGIN GM-CFU in bone marrow (think Monocyte / Macrophage)...
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NBME BONE CARTILAGE REVIEW 2004 - 1 BONE AND CARTILAGE...

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