Thyroid Disease - Thyroid Disease Thyroid Disease Marquis...

Info iconThis preview shows pages 1–18. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Thyroid Disease Thyroid Disease Marquis Gardens June 2, 2004 Dr. William Harper Assistant Professor of Medicine, McMaster University. Endocrinologist, Hamilton General Hospital www.drharper.ca Thyroid Disease Thyroid Disease Hypothyroidism Hyperthyroidism Thyroid Cancer Thyrogen (recombinant human TSH) t 1/2 = 5-7d t 1/2 = < 24 hrs T4 T3 85% (peripheral conversion) 15% Protein binding + 0.03% free T4 Protein binding + 0.3% free T3 (10-20x less than T4) Normal Daily Thyroid Secretion Rate: T4 = 100 ug/day T3 = 6 ug/day ( ratio T4:T3 = 14:1 ) T4 T3 Potency 1 10 Protein Bound 10-20 1 Half-Life 5-7d < 24h Secreted by thyroid 100 ug/d 6 ug/d Thyroid Function: blood tests Thyroid Function: blood tests TSH 0.4 5.0 mU/L Free T4 (thyroxine) 9.1 23.8 pM Free T3 (triiodothyronine) 2.23-5.3 pM TSH Low High FT4 FT4 & FT3 Low Hypothyroidism Low Central Hypothyroid TRH Stim. If equivocal MRI, etc. High Hyperthyroidism High 2 thyrotoxicosis Endo consult FT3, rT3 MRI, -SU RAIU Hypothyroidism Hypothyroidism Decreased thyroid hormone levels Low T4 Possibly Low T3 too. Raised TSH (unless pituitary problem!) Hashimotos Disease Hashimotos Disease Most common cause of hypothyroidism in North America (iodinated salt) Autoimmune lymphocytic thyroiditis Antithyroid antibodies: Thyroglobulin Ab Microsomal Ab TSH-R Ab (block) Females > Males Runs in Families! Subacute (de Quervains) Thyroiditis Subacute (de Quervains) Thyroiditis Preceding viral infection Infiltration of the gland with granulomas Painful goitre Hyperthyroid phase Hypothyroid phase Treatment of Hypothyroidism...
View Full Document

Page1 / 43

Thyroid Disease - Thyroid Disease Thyroid Disease Marquis...

This preview shows document pages 1 - 18. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online