Thyroid Mini-Med

Thyroid Mini-Med - The Thyroid The Thyroid McMaster...

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Unformatted text preview: The Thyroid The Thyroid McMaster Mini-Med School March 24, 2005 Dr. William Harper Assistant Professor of Medicine, McMaster University. Endocrinologist, Hamilton General Hospital www.drharper.ca t 1/2 = 5-7d t 1/2 = < 24 hrs T4 T3 85% (peripheral conversion) 15% Protein binding + 0.03% free T4 Protein binding + 0.3% free T3 (10-20x less than T4) Normal Daily Thyroid Secretion Rate: T4 = 100 ug/day T3 = 6 ug/day ( ratio T4:T3 = 14:1 ) T4 T3 Potency 1 10 Protein Bound 10-20 1 Half-Life 5-7d < 24h Secreted by thyroid 100 ug/d 6 ug/d Thyroid Function: blood tests Thyroid Function: blood tests TSH 0.4 5.0 mU/L Free T4 (thyroxine) 9.1 23.8 pM Free T3 (triiodothyronine) 2.23-5.3 pM Thyroid Disease Thyroid Disease Hypothyroidism Hyperthyroidism Thyroid Nodules & Cancer Hypothyroidism Hypothyroidism Decreased thyroid hormone levels Low T4 Possibly Low T3 too. Raised TSH (unless pituitary problem!) Hashimotos Disease Hashimotos Disease Most common cause of hypothyroidism in North America (iodinated salt) Autoimmune lymphocytic thyroiditis Antithyroid antibodies: Thyroglobulin Ab Microsomal Ab TSH-R Ab (block) Females > Males Runs in Families! Subacute (de Quervains) Thyroiditis Subacute (de Quervains) Thyroiditis Preceding viral infection Infiltration of the gland with granulomas Painful goitre Hyperthyroid phase Hypothyroid phase Treatment of Hypothyroidism...
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Thyroid Mini-Med - The Thyroid The Thyroid McMaster...

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