Toxin_antitoxin - redness will occur indicating a negative result Results can be interpreted as Positive when the test results in a red necrotic

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
Toxin - Antitoxin Neutralization Sayeed Ismail Khatib Lecturer Ibn Sina National College for Medical Studies
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
1. In Vivo (Schick test): Schick test - used to determine whether or not a person is susceptible to diphtheria (Corynebacterium diphtheriae ) . Named after its inventor, Béla Schick (1877-1967) It is a simple procedure. Toxin - Antitoxin Neutralization test
Background image of page 2
A small amount (0.1 ml) of diluted (1/50 MLD) diphtheria toxin is injected intradermally into the arm of the person. Minimum lethal dose (MLD, also LDmin) is the least amount of drug that can produce death in a given animal species under controlled conditions If a person does not have enough antibodies to fight it off, the skin around the injection will become red and swollen, indicating a positive result. This swelling disappears after a few days. If the person has immunity, then little or no swelling and
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 4
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 6
Background image of page 7
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: redness will occur, indicating a negative result. Results can be interpreted as: Positive: when the test results in a red necrotic area of 5-10 mm diameter Pseudo-positive: when there is only a red colored inflammation and it disappears rapidly Negative reaction: No Wheel and erythema 2. In Vitro (Antistreptolysin “O” titration) ASO titre is used for the serological diagnosis of Group A beta-haemolytic streptococcal associated disorders ASO antibodies will be raised after infection with streptococci. Levels greater than 200 units per millilitre are considered significant Measurement of ASO can be useful diagnostically if recent infection with streptococci is known. Diseases include: Rheumatic fever Post streptococcal glomerulonephritis Scarlet fever...
View Full Document

This note was uploaded on 12/21/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

Page1 / 7

Toxin_antitoxin - redness will occur indicating a negative result Results can be interpreted as Positive when the test results in a red necrotic

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online