~BN04 Development of Neural Circuits

~BN04 Development of Neural Circuits - Development of...

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Development of Neural Circuits Lecture 4
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Stages of Cellular Activity 6 distinct stages 1. Neurogenesis 2. Cell migration 3. Differentiation 4. Synaptogenesis 5. Neuronal cell death 6. Synaptic rearrangement ~
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Neurogenesis Precursors (stem) cells Neural tube’s ventricular zone Induction signals Asymmetrical mitosis another stem cell Can divide again neuroblast Cannot divide Neuroblasts neurons & glia ~
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Neuronal Migration Neural crest PNS Guided by cell adhesion molecules (CAMs) Neural tube CNS along radial glia later: along other neurons ~
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Cell Migration Long-distance migration Along radial glia Tangentially to other brain areas Cerebellar neuroblasts Mesoencephalon Rhombencephalon ~
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Differentiation Cell-autonomous Genetic instructions Cell-to-cell interactions Induction signals Critical periods ~
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~BN04 Development of Neural Circuits - Development of...

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