~BN13 neurotransmitters

~BN13 neurotransmitters - Neurotransmitters Lecture 13...

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Neurotransmitters Lecture 13
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CRITERIA NT found in axon terminals NT released by action potentials Synthesis identified External application mimic normal Response Pharmacology same for normal and externally applied NT ~
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NT binds to receptor NT = key Receptor = lock Receptor changes shape determines if EPSP or IPSP receptor subtypes NOT NT ~
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Structure-activity relationship NT fits receptor site Change structure of drug. .. change its affinity increase or decrease may bind to different receptor Behavior mediated by synaptic activity most drugs act at synapse ~
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Acetylcholine - ACh Most abundant NT in Peripheral N.S. also found in Central N.S. Precursor = choline Degraded by acetylcholinesterase- AChE Nicotinic receptor – ionotropic *Nonselective ionophores *Requires 2 Ach for activation Muscarinic receptor - metabotropic ~
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ACh - Distribution Peripheral N.S. Excites somatic muscle
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~BN13 neurotransmitters - Neurotransmitters Lecture 13...

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