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~BN15 Neural plasticity - LTP

~BN15 Neural plasticity - LTP - Neural Plasticity Long-term...

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Neural Plasticity: Long-term Potentiation Lesson 15
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Neural Plasticity Nervous System is malleable learning occurs Structural changes at synapses Changes in synaptic efficiency Long-term potentiation Long-term depression LTP & LTD throughout brain Many different mechanisms ~
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Neural Mechanism of Memory Donald Hebb Short-term Memory Change in neural activity not structural temporary Reverberatory Circuits - cortical loops of activity ~
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Reverberating Loops Maintains neural activity for a period Activity decays ~
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Hebb’s Postulate Long-Term Memory required structural change in brain relatively permanent Hebb Synapse use strengthens synaptic efficiency concurrent activity required pre- & postsynaptic neurons ~
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Long-term Potentiation According to Hebb rule use strengthens synaptic connection Synaptic facilitation Structural changes Simultaneous activity Experimentally produced hippocampal slices associative learning also ~
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Inducing LTP Stimulating electrode Record Presynaptic neuron Postsynaptic neuron
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