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~parkinsonspresentation - Brady Miller

~parkinsonspresentation - Brady Miller - Parkinsons Disease...

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Parkinson’s Disease An Overview of Conventional and Experimental Treatments
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Background Parkinson’s disease is a disorder that affects nerve cells in the part of the brain controlling muscle movement Disease is progressive – signs/symptoms worsen over time Eventually is disabling, but progresses gradually Believed to be caused by genetics, environmental factors or a combination of the two
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Parkinson’s Disease Stats First desribed by James Parkinson in 1817 Affects ~1 million in the U.S. Onset typically between 50-60 years of age, and slowly progresses with age Average onset is 62.4 years of age
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Neurological Basis “Neurodegenerative Disease” : caused by degeneration (dysfunction and death) of neurons within the brain (nigrastriatal pathway of the basal ganglia) NORMAL BRAIN FUNCTION – Basal Ganglia Cells in substantia nigra produce/release dopamine Dopamine released by SN neurons lands on neurons of other brain centers, controlling their firing Main targets are caudate nucleus and putamen (striatum) This basal ganglia pathway is involved in regulation of movement
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Neurological Basis PARKINSON’S BRAIN FUNCTION–Basal Ganglia Cells of substantia nigra degenerate These cells can no longer produce adequate amounts of dopamine Neurons of striatum, etc. are no longer well regulated, thus do not behave in normal manner Results in loss of control of movements – leads to symptoms characteristic of Parkinson’s disease
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