2 Replication & Repair

2 Replication & Repair - 1 Molecular Biology Part II:...

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Unformatted text preview: 1 Molecular Biology Part II: The Central Dogma The Hereditary Molecule Replication & Repair 2 From “M&M” to “Results” • Previously we focused on Materials and Methods per se • Now: course focus changes to inferences from experiments: – structures and functions of hereditary molecules – empirical tests and interpretations 3 Griffith’s (1928) experiment with Streptococcus (= Diplococcus ) pneumoniae Living, Non-Virulent Cells Living, Virulent Cells 4 Avery, McLeod, & McCarty (1944): isolation of “the transforming principle” 5 Oswald Avery, from Judson HF The Eighth Day of Creation 6 Data from Avery, McLeod, & McCarty 7 Data from Avery, McLeod, & McCarty 8 “The Transforming Principle” – alternative interpretations (Lederberg 1994, 1956) • A specific mutagen with a special ability to direct a particular gene to mutate in a specific direction • A polysaccharide autocatalyst (perhaps complexed with DNA) that primes an enzymatic reaction for polysaccharide synthesis 9 “The Transforming Principle” – alternative interpretations...
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This note was uploaded on 12/24/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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2 Replication & Repair - 1 Molecular Biology Part II:...

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