4 Eukaryotes A&B - Molecular Biology Part IV...

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1 Molecular Biology Part IV: Eukaryotes Regulation, Hyperdrive, & the C- Value Paradox A. Multicellularity & Similarities to prokaryotes B. Introduction to differences
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2 Kinemage Loaded on computers in Sci 2530 See Lab Manual – Last pages Purpose: visualize binding between DNA sequences and regulatory proteins
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3 “That gene control is achieved by regulating transcription is the main lesson of molecular biology in the past 20 years” -Eric H. Davison embryologist Caltech
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4 The most pressing questions of the moment concern gene expression, in particular the nature of the network of regulatory events that must be involved in the development of an adult eukaryote from its embryo. Are genes controlled in a temporal cascade? How are the geographical distinctions between parts of the organism originally established and then perpetuated and extended? How far, indeed, can networks involved in gene regulation explain the process of development? Benjamin Lewin, 1994 Genes V
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5 … regulatory genes perform multiple roles in development: The repertoire of regulatory genes is evolutionarily limited,
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