Becker Muscular Dystrophy-1

Becker Muscular Dystrophy-1 - It Affects Cardiac Muscle...

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Unformatted text preview: It Affects Cardiac Muscle Skeletal Muscle Nervous System increase in serum Creatine Kinase which is a marker for muscle damage Schizophrenia or related spectrum disorders susceptibility to mental illnesses mental retardation It Increases Chances of Exertional cramping and Myoglobinuria (severe muscular problems Exercise intolerance A fault in Dystrophin leads to the formation of a faulty protein in muscle fibers. When Dystrophin is abnormal the muscle fibers gradually break down and the muscles slowly become weaker. These Dystrophin abnormalities in muscle provide a very good test for the diagnosis of Becker MD. ? ? X Several affected males in a large portion of people reported by Becker (1957) had produced children and the resulting pedigree pattern was consistent with X- linked inheritance. Since it is X-Linked recessive, Becker MD ONLY affects males, but may be transmitted by unaffected female carriers of the gene to their sons. The sons of carriers each have a 50:50 chance of being affected. The daughters of carriers each have a 50:50 chance of being carriers. The mothers and sisters of affected males may be carriers and may need to be tested. The sons of affected males do not carry the gene and will not be affected or transmit the gene. However, all the daughters of affected males are carriers of the gene and may transmit the disorder to the following generation. Cure? There is no cure at present Research is proceeding to try to find a way to induce the muscles to form Dystrophin. Any treatment, which may be found to be effective in Duchenne MD, would theoretically be effective also in the Becker type. Diagnosis before the age of two or three (before symptoms...
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Becker Muscular Dystrophy-1 - It Affects Cardiac Muscle...

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