behcetsr - BEHETS DISEASE Idiopathic multisystem disease...

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1 BEHÇET’S DISEASE Idiopathic multisystem disease More common in men Occurs in 3 rd - 4 th decade Highest incidence in Mediterranean region and Japan Associated with HLA-B5
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2 BEHÇET’S DISEASE Aetiology Unknown Various bacteria and viruses suggested No good evidence to suggest any of them Perpetuated by autoimmune response and CD4 + T-cells Tumour necrosis factor (TNF) thought to be important
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3 BEHÇET’S DISEASE Systemic Involvement (1) Oral aphthous ulceration – 100%
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4 BEHÇET’S DISEASE Systemic Involvement (2) Genital ulceration – 90%
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5 BEHÇET’S DISEASE Systemic Involvement (3) Skin lesions – 80% Erythema Nodosum Acneiform Uveitis 70% (inflam. of iris, ciliary body or choroid)
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6 BEHÇET’S DISEASE Systemic Involvement (4) CNS involvement – strokes, fits Major vessels eg superior Vena cava obstruction Increased skin response to trauma eg
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This note was uploaded on 12/24/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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behcetsr - BEHETS DISEASE Idiopathic multisystem disease...

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