BENIGN LEUCOCYTES DISORDERS 3.57.51 PM

BENIGN LEUCOCYTES DISORDERS 3.57.51 PM - LEUCOCYTESBENIGN...

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    LEUCOCYTES BENIGN  DISORDERS Dr. Tariq Roshan Department of Hematology
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Contents. Leucocytosis and leucopenia Granulocytosis and agranulocytosis Neutrophilia and neutropenia Eosinophilia Lymphocytosis and lymphopenia Monocytosis Basophilia Physiological and pathological conditions of Granulocytes Monocytes Lymphocytes
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LEUCOCYTES BENIGN DISORDERS Quantitative Change in number Terminology Cytosis / philia Increase in number Cytopenia Decrease in number Qualitative Morphologic changes Functional changes
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LEUCOCYTES BENIGN DISORDERS   Quantitative changes Relative vs Absolute values Total white blood cell count Differential count Absolute count Differential gives the relative percentage of  each WBC Absolute value gives the actual number of  each WBC/mm 3  of blood Calculation: absolute count= Total WBC x  percent
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LEUCOCYTES BENIGN DISORDERS   Quantitative changes Regulation of cell production Regulatory mechanisms must operate in  close controlled way Haemopoietic growth factors The control of cell death Inhibitors of cell proliferation Stromal cell factors (cell-cell and cell- matrix interaction)
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LEUCOCYTES BENIGN DISORDERS   Quantitative changes (LEUCOCYTOSIS) Leucocytes Phagocytes Granulocytes Neutrophils Eosinophils Basophils Mononuclear phagocytic cells Monocytes Macrophage and denderetic cells Lymphocytes B-cells T-cells
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LEUCOCYTES BENIGN DISORDERS   Quantitative changes (LEUCOCYTOSIS) Definition Raised TWBC due to elevation of any of  a single lineage. Note: elevation of the minor cell populations can  occur without a rise in the total white cell count. Normal reference range (adult 21 years) 4.5 -- 11.0 x 10 9 /L
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LEUCOCYTES BENIGN DISORDERS   Quantitative changes (LEUCOPENIA) Definition TWBC lower than the reference range  for the age is defined as leucopenia Leucopenia may affect one or more  lineages and it is possible to be severely  neutropenic or lymphopenic without a  reduction in total white cell count.
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LEUCOCYTES BENIGN DISORDERS   Quantitative changes (contd.) Granulocytosis Increase in the count of all or one of the  granulocytic component Neutrophils Basophils Eosinophils Agranulocytosis Decrease in the count of all or one  granulocytic component
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LEUCOCYTES BENIGN DISORDERS   Quantitative changes (NEUTROPHILIA) Definition Increase in the number of neutrophils and / or its  precursors In adults count >7.5 x 10 9 /L but the counts are age  dependent Increase may results from alteration in the normal steady 
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BENIGN LEUCOCYTES DISORDERS 3.57.51 PM - LEUCOCYTESBENIGN...

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