Bone marrow morphology 3.57.51 PM

Bone marrow morphology 3.57.51 PM - Examination of bone...

Info icon This preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
Examination of bone marrow aspirates
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Aspiration of the BM Satisfactory samples can usually be aspirated from the Sternum Anterior or posterior iliac spines Aspiration from only one site can give rise to misleading information; this is particularly true in aplastic anaemia as the marrow may be affected partially.
Image of page 2
There is little advantage in aspirating more than 0.3 ml of marrow fluid from a single site for morphological examination as this increases peripheral blood dilution.
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Bone marrow aspirate A bone marrow film should first be examined macroscopically to make sure that particles or fragments are present. Bone marrow aspirates which lack particles may be diluted with peripheral blood and may therefore be unrepresentative . An ideal bone marrow film with particles is shown.
Image of page 4
Even films without fragments are worth examining as useful information may be gained. However, assessment of cellularity and megakaryocyte numbers is unreliable and dilution with peripheral blood may lead to lymphocytes and neutrophils being over- represented in the differential count.
Image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Cells of the bone marrow Erythroid series Myeloid series Megakaryocytic series
Image of page 6
Erythroid series *Proerythroblast **Early erythroblast ***Intermediate erythroblast ****Late erythroblast
Image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Erythroid precursors Normal red cells are produced in the bone marrow from erythroid precursors or erythroblasts. The earliest morphologically recognisable red cell precursor is derived from an erythroid progenitor cell which in turn is derived from a multipotent haemopoietic progenitor cell.
Image of page 8
proerythroblast Normal proerythroblast [dark red arrow] in the bone marrow. This is a
Image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern