Bone marrow morphology 3.57.51 PM

Bone marrow morphology 3.57.51 PM - Examination of bone...

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Examination of bone marrow aspirates
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Aspiration of the BM Satisfactory samples can usually be aspirated from the Sternum Anterior or posterior iliac spines Aspiration from only one site can give rise to misleading information; this is particularly true in aplastic anaemia as the marrow may be affected partially.
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There is little advantage in aspirating more than 0.3 ml of marrow fluid from a single site for morphological examination as this increases peripheral blood dilution.
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Bone marrow aspirate A bone marrow film should first be examined macroscopically to make sure that particles or fragments are present. Bone marrow aspirates which lack particles may be diluted with peripheral blood and may therefore be unrepresentative . An ideal bone marrow film with particles is shown.
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Even films without fragments are worth examining as useful information may be gained. However, assessment of cellularity and megakaryocyte numbers is unreliable and dilution with peripheral blood may lead to lymphocytes and neutrophils being over- represented in the differential count.
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Cells of the bone marrow Erythroid series Myeloid series Megakaryocytic series
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Erythroid series *Proerythroblast **Early erythroblast ***Intermediate erythroblast ****Late erythroblast
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Erythroid precursors Normal red cells are produced in the bone marrow from erythroid precursors or erythroblasts. The earliest morphologically recognisable red cell precursor is derived from an erythroid progenitor cell which in turn is derived from a multipotent haemopoietic progenitor cell.
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proerythroblast Normal proerythroblast [dark red arrow] in the bone marrow. This is a
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This note was uploaded on 12/24/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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Bone marrow morphology 3.57.51 PM - Examination of bone...

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