Cerebral Circulation

Cerebral Circulation - PHYSIOLOGY CEREBRAL CIRCULATION...

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PHYSIOLOGY CEREBRAL CIRCULATION
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CEREBRAL BLOOD FLOW CBF: Cerebral perfusion pressure cerebral vascular resistance CPP: MAP-ICP Under normal condition the CBF is coupled to the energy of brain, the regulatory mechanisms acting on the arterioles to maintain CBF sufficient to meet the metabolic needs
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Factors affecting the cerebral vasculature CHEMOREGULATIO N : Any change in Pco2 has a direct effect on cerebral vessels Changes in extracellular PH directly affect the vessel caliber AUTOREGULATION : A change in cerebral perfusion pressure results in a compensatory change in vessel caliber
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Energy requirements differ in different parts of the brain. White matter: 20-50ml/100g/min Gray matter : as high as 100ml/100glmin autoregulation maintains the cerebral perfusion pressure within certain limits without significantly altering cerebral blood flow
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A drop in CPP produces vasodilatation A rise in CPP produce vasoconstriction autoregulation fails
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Cerebral Circulation - PHYSIOLOGY CEREBRAL CIRCULATION...

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