CPC2604 3.57.51 PM

CPC2604 3.57.51 PM - Methodologicaldevelopment&...

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    in-vivo  determination of Platelet  post-menopausal women by  Flow cytometry Jamaludin  Department of Hematology, School of Medical  Sciences, University Sains Malaysia.
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Introduction Platelet Activation  To contribute in haemostasis, platelets need to  be activated Pathological over activation plays a major role  in pathophysiology of  arterial thrombosis  (Schmitz et  al.1998) markers are noted in thrombotic disorders like  (Robert et  al. 2001, Michelson et al. 1999, Koksch et al. 2001)
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Implications of platelet activation Implications of platelet activation Post-menopausal women have higher risk  of  thrombotic  diseases  compared  to  pre- menopausal women  (Wenger et al.1993) Effect  of  estrogen  on  endothelial  production of NO, PGI 2 , ET-1 which in turn  inhibits platelet activation  (Darkow et al. 1997, Wakasugi et  al. 1989)
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Techniques  for  in-vivo  analysis  of  Platelet  activation Platelet  Aggregometry,  Plasma  assay  of  - thromboglobulin,  Platelet  factor  4,  Soluble  P-selectin  limitations: as inability to measure association with the condition  detect a distinct platelet population and results in  in-vitro  activation  (Chong BH.,1994) Introduction
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High diagnostic sensitivity in peripheral  vascular disease  (Koksch M. et al., 2001) This technique is devoid of the said  limitations Local development of this technique will  be useful Flow cytometric analysis of platelet  activation
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No previous study was done to  determine platelet activation  markers using flow cytometer in  post menopausal women.
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Objectives Primary objective To develop and optimize the technique locally. Secondary objectives
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CPC2604 3.57.51 PM - Methodologicaldevelopment&...

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